Leigh Duffy
Leigh Duffy March 19, 2019

Minimize Your Risk of Type IV Allergies

More and more hospitals are moving to a non-latex environment to eliminate the risk of an adverse response to latex and to minimize sensitivities. There has been an increasing number of cases reported of healthcare workers developing Type IV chemical allergies after making the switch to non-latex gloves.
Type IV allergies, caused by standard chemical accelerators, are on the rise with up to 82% of reported glove-associated allergic contact dermatitis attributed to chemical accelerators.1, 2 Since the mid-1990s, the sensitization frequency of thiurams appear to be on the decline, while there are an increasing number of patch test reactions among healthcare workers to diphenylguanidine (DPG) and standard carbamate mixes including zinc diethyldithiocarbamate (ZDEC) and zinc dibutyldithiocarbamate (ZDBC).3
How can you help to reverse this trend and eliminate glove-induced Type IV chemical allergies at your facility? Download these tips today to minimize risk factors.


1. Higgins C, Palmer A, Cahill J, Nixon R. Occupational skin disease among Australian healthcare workers: a retrospective analysis from an occupational dermatology clinic, 1993-2014. Contact Dermatitis. 2016;75(4):213-22.
2. Heese A, van Hintzenstern J, Peters KP, Koch HU, Hornstein OP. Allergic and irritant reactions to rubber gloves in medical health services. Spectrum, diagnostic approach, and therapy. J Am Acad Dermatol. 1991;25 (5 Pt 1):831-839.
3. Uter W, Warburton K, Weisshaar E, Simon D, Ballmer-Weber B, Mahler V, Fuchs T, Geier J, Wilkinson M. Patch test results with rubber series in the European Surveillance System on Contact Allergies (ESSCA) 2013/14 Contact Dermatitis 2016;