Preventing surgical site infections (SSIs) in the OR is a primary focus for all perioperative teams. SSIs are not only an economic burden but for some patients are catastrophic, causing significant morbidity and mortality.1 For the healthcare system, SSIs are costly with some countries including the USA and more recently Australia, adopting pay-for-performance systems whereby additional costs associated with specific SSIs are either not covered by insurance or where a hospital is penalized for each SSI by the denial of government funding.2 Healthcare workers are required to perform multiple infection prevention best practices to protect against transmission of potentially infectious agents and provide a safe environment. Personal protective equipment has never been more important. Practices such as double gloving, utilizing antimicrobial technology in surgical and decontamination gloves (available only in Canada), properly handling surgical smoke and wearing surgical masks when indicated, utilizing disposable antimicrobial barrier table linens, turnover kits, patient positioners and practicing sharps safety are all important considerations in improving safety outcomes. Please read more about potential infection control issues, exposure risks and preventative measures, along with other safety recommendations to maintain work control best practices and provide safe and effective care.